Thermo Fisher Scientific ATM Monoclonal Antibody (2C1)
ATM 단백질을 인식하는 Mouse Monoclonal Antibody (Clone 2C1). Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. Human, Mouse, Rat 등 반응. 항원 친화 크로마토그래피로 정제된 고품질 항체. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution / Condition | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | View 2 publications |
| Flow Cytometry (Flow) | Assay-dependent | - |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | 1–10 µg/mL | - |
| ChIP assay (ChIP) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | C. elegans, Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C1 |
| Immunogen | Recombinant protein expressed in E. coli corresponding to amino acids 2577–3056 of ATM |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.99 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_557657 |
Product Specific Information
- Recommended positive controls: SK-N-SH, HeLa, HeLa nuclear extract
- Predicted molecular weight: ~350 kDa
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Ataxia-telangiectasia Mutated (ATM) is a protein belonging to the PI3/PI4 kinase family.
Ataxia-telangiectasia is a rare autosomal recessive disorder characterized by progressive neurologic degeneration, immunologic deficiency, and increased risk of lymphoid cancer.
The ATM gene encodes a protein kinase that phosphorylates various cell-cycle regulators such as P53, Mdm2, BRCA1, and SMC1, and plays a crucial role in repairing double-stranded DNA breaks caused by ionizing radiation and mutagens.
ATM activation triggers a cascade of kinase reactions regulating cell cycle, apoptosis, and DNA damage repair.
Defects in ATM lead to hypersensitivity to radiation and impaired DNA damage response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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