Thermo Fisher Scientific TIEG1 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:2,000–1:10,000

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. It acts as a transcriptional repressor regulating cell growth and binds to the consensus sequence 5'-GGTGTG-3'. Induced by TGF-beta, KLF10 links TGF-beta-mediated signaling to pancreatic epithelial cell growth regulation. It promotes apoptosis through the mitochondrial pathway and may inhibit Smad7 expression in bronchial epithelial cells. KLF10 is ubiquitously expressed in most tissues and may mediate up-regulation of TGFBI in VHL-deficient tumors. Overexpression has been associated with renal clear cell carcinoma and other tumors. KLF11, a related zinc finger transcription factor, binds SP1-like sequences in epsilon- and gamma-globin promoters, inhibiting cell growth and causing apoptosis. Defects in this gene can cause maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.