Thermo Fisher Scientific TIEG1 Polyclonal Antibody
Rabbit 폴리클로날 항체로 KLF10 단백질을 타겟하며, Western blot에 1:1,000 희석으로 사용 가능. 액상 형태로 4°C에서 보관, 습빙 상태로 배송. 세포 성장 및 TGF-beta 신호 조절 연구에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 430–480 of KLF10 (UniProt ID: Q13118-1, NCBI Node ID: 9606) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. It acts as a transcriptional repressor regulating cell growth and apoptosis. KLF10 binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta, linking TGF-beta-mediated signaling to pancreatic epithelial cell growth regulation. It may inhibit Smad7 expression in bronchial epithelial cells and is ubiquitously expressed in most tissues. Overexpression of KLF10 has been associated with renal clear cell carcinoma and other tumors.
KLF11, a related zinc finger transcription factor, binds SP1-like sequences in epsilon- and gamma-globin promoters, inhibiting cell growth and causing apoptosis. Mutations in KLF11 are linked to maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: A302-015A-M_KLF10_Q13118-1_Rabbit.svg, A302-015A-M_KLF10_Q13118-1_Rabbit_PDP.jpeg)
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