Thermo Fisher Scientific SDHB Polyclonal Antibody
Thermo Fisher Scientific SDHB Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 고품질 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며 항원 친화 크로마토그래피로 정제되었습니다. 미토콘드리아 내막의 Complex II 연구에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 66–280 of Human SDHB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.42 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547317 |
Product Specific Information
- Recommended positive controls: NCI-H929, mouse brain
- Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (90%), Xenopus laevis (93%), Dog (98%), Pig (98%), Chicken (90%), Rhesus Monkey (100%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Complex II of the respiratory chain is specifically involved in the oxidation of succinate and carries electrons from FADH to CoQ.
This complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane.
The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters that may comprise the iron-sulfur centers of the enzyme.
Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, supporting a link between mitochondrial dysfunction and tumorigenesis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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