Thermo Fisher Scientific TAP2 Polyclonal Antibody
TAP2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB, IHC, ICC 등 다양한 응용에 적합합니다. 고순도(>95%) 항체이며, 인간·마우스·랫트 반응성을 가지며 항원 친화 크로마토그래피로 정제되었습니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length human TAP2 (UniProt ID: Q03519-1, amino acids 1–686) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2554051 |
Product Specific Information
- Detects endogenous TAP2 protein at approximately 72 kDa.
- Purity >95% by SDS-PAGE.
Target Information
The TAP2 gene encodes a membrane-associated protein belonging to the ATP-binding cassette (ABC) transporter superfamily. These proteins facilitate the transport of various molecules across cellular membranes. TAP2 is part of the MDR/TAP subfamily, which contributes to multidrug resistance and antigen presentation.
TAP2 forms a heterodimer with ABCB2 to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in TAP2 may be linked to ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing results in two isoforms with differing peptide selectivity and MHC class I surface expression restoration.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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