Thermo Fisher Scientific KDM5B Polyclonal Antibody
KDM5B 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 사용 가능. 인간 시료에 반응하며 C-말단 펩타이드 면역원으로 제작됨. 액상 형태, 0.5 mg/mL 농도, PBS + 2% sucrose buffer에 보관. -20°C에서 보관, 반복 동결·해동 피해야 함.
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Applications
- Western Blot (WB): Tested at 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human KDM5B (aa 787–836) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2576731 |
Product Specific Information
Peptide sequence:
EMKKFPDNDL LRHLRLVTQD AEKCASVAQQ LLNGKRQTRY RSGGGKSQNQ
Target Information
KDM5B is a histone demethylase that demethylates Lys-4 of histone H3, thereby playing a central role in the histone code. It does not demethylate histone H3 Lys-9 or Lys-27. KDM5B demethylates trimethylated, dimethylated, and monomethylated H3 Lys-4. It acts as a transcriptional corepressor for FOXG1B and PAX9 and promotes the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. Conversely, KDM5B may act as a tumor suppressor in melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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