Thermo Fisher Scientific Phospho-PFKP (Tyr52) Polyclonal Antibody

Thermo Fisher Scientific Phospho-PFKP (Tyr52) Polyclonal Antibody

Applications

• Western Blot (WB): 1:100–1:3,000

Species Reactivity

• Human
• Mouse
• Rat

Product Specifications

Product Specific Information

Antibody detects endogenous levels of PFKP only when phosphorylated at Y52.

Target Information

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the γ-phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this mechanism, protein kinases mediate most signal transduction in eukaryotic cells, regulating metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and movement, apoptosis, and differentiation.

With more than 500 gene products, the protein kinase family is one of the largest in eukaryotes. It is classified into 8 major groups based on sequence comparison of tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group includes 63 kinases such as:

• Cyclic nucleotide-regulated protein kinases (PKA & PKG)
• Diacylglycerol/phospholipid-dependent protein kinase C (PKC)
• RAC/Akt protein kinases
• Kinases that phosphorylate G protein-coupled receptors (ARK)
• Kinases that phosphorylate ribosomal protein S6 (RSK)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.