Thermo Fisher Scientific ZO-1 Monoclonal Antibody (ZO1-1A12), Alexa Fluor 555
ZO-1 단백질을 표적하는 Mouse 모노클론 항체로 Alexa Fluor 555 형광 표지. 면역세포화학(ICC/IF)에 적합하며 Dog 및 Human 반응성 확인. 고순도 친화성 크로마토그래피 정제, 4°C 암조건 보관.
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Thermo Fisher Scientific ZO-1 Monoclonal Antibody (ZO1-1A12), Alexa Fluor 555
Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 1–10 µg/mL
Publications: View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Published Species | Dog, Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ZO1-1A12 |
| Immunogen | Human recombinant ZO-1 fusion protein (amino acids 334–634) |
| Conjugate | Alexa Fluor™ 555 |
| Excitation / Emission Max | 553 / 568 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2663168 |
Additional Formats:
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 594
- Alexa Fluor 647
- FITC
- Request custom conjugation available
Target Information
ZO-1 forms complexes with either ZO-2 or ZO-3. These proteins associate with claudin, occludin, and F-actin at tight junction strands, linking the actin cytoskeleton and tight junctions. ZO-1 expression is reduced in many breast cancer lines.
ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, while ZO-1 is also expressed at cardiac myocyte junctions.
ZO-1 is located on the cytoplasmic membrane surface of intercellular tight junctions and may be involved in signal transduction at cell-cell junctions.
Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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