Thermo Fisher Scientific ITGAM Monoclonal Antibody (OTI2D11), TrueMAB
인간 ITGAM(CD11b) 단백질을 인식하는 Mouse IgG1 단일클론 항체. Western blot 및 파라핀 조직 면역조직화학(IHC) 적용 가능. 보존제 없이 동결건조된 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D11 |
| Immunogen | Full length human recombinant protein of human ITGAM produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform additional desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that forms a heterodimer with integrin beta-2 (CD18).
This complex, known as integrin alpha-M beta-2, Mac-1, or CR3, mediates interactions with ICAMs, CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X.
CD11b is expressed on:
- Monocytes/macrophages
- Granulocytes
- Activated lymphocytes
- NK cell subsets
- Dendritic cells
- Microglia in the brain
Expression levels vary by cell type and tissue, increasing during monocyte maturation.
Peritoneal macrophages exhibit higher CD11b levels than splenic macrophages.
CD11b dysfunction is associated with systemic lupus erythematosus and ITGAM-related susceptibility to autoimmune disorders.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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