Thermo Fisher Scientific PDGFRB Monoclonal Antibody (18A2), PE
인간 PDGFRB(CD140b)를 인식하는 마우스 단클론 항체로 PE 형광체가 결합되어 있습니다. Flow Cytometry에 적합하며, 세포 표면의 PDGFRB 발현 분석에 활용됩니다. 액상 형태로 제공되며 4°C 암소 보관이 필요합니다.
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Thermo Fisher Scientific PDGFRB Monoclonal Antibody (18A2), PE
Applications
- Flow Cytometry (Flow): 20 µL/1×10⁶ cells
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 18A2 |
| Immunogen | CD140b-transfected NIH 3T3 cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS (pH 7.4) with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152491 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD140b / PDGF-RB, the 180–190 kDa beta chain of platelet-derived growth factor receptor. It is widely expressed on various mesenchymal-derived cells and plays pro-proliferative roles.
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for mesenchymal-origin cells. The receptor may form homodimers or heterodimers with PDGF receptor alpha, depending on the bound growth factor. The PDGFRB gene is located on chromosome 5, near genes for GM-CSF and M-CSF receptor, and may be involved in 5-q syndrome. A translocation between chromosomes 5 and 12 that fuses PDGFRB (CD140b) with ETV6 results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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