Thermo Fisher Scientific PDGFRB Monoclonal Antibody (18A2), PE

Thermo Fisher Scientific PDGFRB Monoclonal Antibody (18A2), PE

Applications

• Flow Cytometry (Flow): 20 µL/1×10⁶ cells
• View 1 publication

Product Specifications

Additional Formats

• Unconjugated (MA1-10100)
• APC (MA1-10101)
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD140b / PDGF-RB, the 180–190 kDa beta chain of platelet-derived growth factor receptor. It is widely expressed on various mesenchymal-derived cells and plays pro-proliferative roles.

Target Information

PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for mesenchymal-origin cells. The receptor may form homodimers or heterodimers with PDGF receptor alpha, depending on the bound growth factor. The PDGFRB gene is located on chromosome 5, near genes for GM-CSF and M-CSF receptor, and may be involved in 5-q syndrome. A translocation between chromosomes 5 and 12 that fuses PDGFRB (CD140b) with ETV6 results in chronic myeloproliferative disorder with eosinophilia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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