Thermo Fisher Scientific IKK beta Monoclonal Antibody (10A2)

Thermo Fisher Scientific IKK beta Monoclonal Antibody (10A2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-15319 targets IKBKB in indirect ELISA and WB applications, showing reactivity with human samples.
The immunogen used for MA5-15319 is a purified recombinant fragment of IKBKB expressed in E. coli.

Target Information

Phosphorylation of serine residues on IκB proteins by IKK kinases, including IKBKB, marks them for degradation via the ubiquitination pathway, enabling activation of the NF-κB complex.
IKK beta (IKBKB) is a serine kinase essential for the NF-κB signaling pathway, activated by inflammatory cytokines, bacterial or viral products, DNA damage, and other cellular stresses.
It functions as part of the canonical IKK complex, phosphorylating inhibitors of NF-κB on critical serine residues, leading to their polyubiquitination and proteasomal degradation.
This process releases NF-κB, allowing it to enter the nucleus and activate transcription of genes involved in immune response, growth control, and anti-apoptotic mechanisms.
Mutations in the IKBKB gene can cause Immunodeficiency 15 (IMD15).

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.