Thermo Fisher Scientific MSR1 Monoclonal Antibody (OTI9E5), TrueMAB

Applications and Tested Dilution

• Western Blot (WB): 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The CD204 (MSR1) gene encodes class A macrophage scavenger receptors, which include three isoforms (types 1, 2, and 3) generated by alternative splicing. These macrophage-specific trimeric integral membrane glycoproteins are involved in physiological and pathological processes such as atherosclerosis, Alzheimer’s disease, and host defense.

• Type 1 and 2 isoforms mediate endocytosis of modified LDLs.
• Type 3 isoform lacks this function due to altered intracellular processing and retention in the endoplasmic reticulum.
• Type 3 can inhibit types 1 and 2, suggesting a regulatory mechanism for scavenger receptor activity.

Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.