Thermo Fisher Scientific MKP1/MKP2 Polyclonal Antibody
MKP1/MKP2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat에 반응하며, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관하며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DUSP1 (Accession P28562), corresponding to amino acid residues L270–E320 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818452 |
Product Specific Information
Antibody detects endogenous levels of total MKP1/2.
Target Information
There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP2 (DUSP4) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs (ERK, JNK, p38). It contains one Rhodanese domain and one tyrosine-protein phosphatase domain. MKP2 is expressed in a variety of tissues and localized in the nucleus. Transcription factor E2F-1 acts as a transcriptional regulator of MKP2. The E2F-1/MKP2 pathway mediates apoptosis under oxidative stress, and MKP2 suppresses tumor formation. MKP2 is a novel transcription target of p53 in mediating apoptosis via a 10-bp palindrome motif (CTGGCGCCAG) in the MKP2 promoter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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