Thermo Fisher Scientific FGF 4 Polyclonal Antibody
FGF4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(P), ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| ELISA | 0.01–0.1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the N-terminus of Fibroblast Growth Factor 4 (FGF4) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Recombinant protein FGF-4
- Cellular location: Secreted
Target Information
Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family with broad mitogenic and cell survival activities. It plays key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis.
FGF4 exhibits strong oncogenic transforming activity and acts as a potent angiogenic factor, expressed in several highly vascularized tumors and adult mouse tissues such as testis, intestine, and brain.
Studies suggest its involvement in bone morphogenesis and limb development via the sonic hedgehog (SHH) signaling pathway. Additionally, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation.
Recent findings indicate a growth-promoting role in human embryonic stem cells and a feedback inhibition mechanism through a novel FGF4 splice isoform that may promote differentiation at later developmental stages.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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