Thermo Fisher Scientific Mast Cell Chymase Recombinant Rabbit Monoclonal Antibody (JB74-32)
Recombinant rabbit monoclonal antibody specific for human Mast Cell Chymase. Validated for WB and IHC applications. High purity Protein A–purified liquid form with 1 mg/mL concentration. Suitable for cardiovascular and mast cell research. For research ...
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:800 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JB74-32 |
| Immunogen | Synthetic peptide within Human Mast Cell Chymase (aa 198–247) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2848571 |
Product Specific Information
Positive Control: Rat spleen and mouse spleen tissue lysates, human tonsil tissue, human skin tissue.
Target Information
Mast Cell Chymase is a chymotryptic serine proteinase belonging to the peptidase family S1. It is expressed in mast cells and plays roles in extracellular matrix degradation, submucosal gland secretion regulation, and generation of vasoactive peptides. In cardiac and vascular tissues, it converts angiotensin I to angiotensin II, contributing to blood pressure regulation and cardiovascular pathology such as hypertension, cardiac hypertrophy, and heart failure. This gene is located on chromosome 14q11.2 within a cluster of protease genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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