Thermo Fisher Scientific Phospho-MSK1 (Ser376) Polyclonal Antibody
MSK1의 Ser376 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot 및 Immunocytochemistry에 적합. 인산화된 MSK1의 내인성 수준 검출에 유용. 인간 및 마우스 시료에 반응. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RPS6KA5 (Accession O75582), corresponding to amino acid residues around phosphorylated Ser376. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816183 |
Product Specific Information
This antibody detects endogenous levels of MSK1 only when phosphorylated at Serine 376.
Target Information
RPS6KA5 (MSK1) is a serine/threonine protein kinase essential for the regulation of various cellular processes. It is required for the mitogen- or stress-induced phosphorylation of transcription factors such as CREB1 and ATF1, and for regulation of RELA, STAT3, and ETV1/ER81. MSK1 contributes to gene activation by histone phosphorylation and plays a role in inflammatory gene regulation. It phosphorylates CREB1 and ATF1 in response to stimuli such as UV-C irradiation, EGF, and anisomycin. MSK1 also regulates RELA transcriptional activity in response to TNF and glucocorticoid signaling, associates with the glucocorticoid receptor NR3C1, and represses inflammatory gene expression. In skeletal myoblasts, it is required for RELA phosphorylation at Ser-276 during oxidative stress, and in erythropoietin-stimulated cells, it is necessary for STAT3 Ser-727 phosphorylation and transcriptional regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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