Thermo Fisher Scientific Phospho-NBS1 (Ser343) Polyclonal Antibody
Ser343 위치에서 인산화된 NBS1 단백질을 특이적으로 검출하는 폴리클로날 항체로, Western blot 및 면역세포화학에 적합합니다. 인간, 마우스, 랫트 반응성. 고순도 정제, 1 mg/mL 농도, PBS/glycerol buffer로 안정적 보관.
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NBN (Accession O60934), corresponding to amino acid residues around phosphorylated Ser343 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816179 |
Product Specific Information
This antibody detects endogenous levels of p95/NBS1 only when phosphorylated at Serine 343.
Target Information
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This complex is implicated in Nijmegen breakage syndrome, an autosomal recessive disorder associated with increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity. It demonstrates a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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