Thermo Fisher Scientific NUP107 Monoclonal Antibody (39C7)
NUP107 단백질을 인식하는 마우스 단클론 항체로, WB 및 ICC/IF에 적합합니다. 다양한 종(인간, 마우스, 효모 등)에 반응하며 액상 형태로 제공됩니다. 핵공복합체 연구 및 세포면역형광 분석에 활용됩니다.
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Thermo Fisher Scientific NUP107 Monoclonal Antibody (39C7)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:500 | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Chicken, Fruit fly, Horse, Human, Mouse, Pig, Rat, Yeast |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 39C7 |
| Immunogen | Yeast nuclear preparation |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Tissue culture supernatant |
| Contains | 5 mM sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2154446 |
Product Specific Information
- For immunofluorescence on yeast cells, use MCA-39C7 diluted 1:100 to 1:500.
- For immunofluorescence on mammalian cells, use 1:50 to 1:100.
Target Information
The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm.
NUP107 is part of the NUP107–160 hetero-oligomeric complex including NUP160, NUP133, NUP96, and yeast homolog sec13p.
While most of the NUP107–160 complex localizes to the nuclear pore, a fraction is found at kinetochores and spindle poles during mitosis, associated with Mad1, Mad2, Bub3, and Cdc20.
Immunodepletion of the NUP107–160 complex leads to defective spindle assembly, indicating multiple functions.
NUP107 has also been identified as an HIV dependency factor (HDF), suggesting potential as a drug target in HIV treatment.
Multiple isoforms of NUP107 exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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