Thermo Fisher Scientific NUP107 Monoclonal Antibody (39C7)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:50-1:500

View 3 publications 3 publications

Product Specifications

Species Reactivity

Bovine, Chicken, Fruit fly, Horse, Human, Mouse, Pig, Rat, Yeast

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

39C7

Immunogen

Yeast nuclear preparation. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NUP107,uniProtId:Q10331-1,ncbiNodeId:-23,antigenRange:1-813,antigenLength:813,antigenImageFileName:MA1-10031_NUP107_Q10331-1_House_mouse.svg,antigenImageFileNamePDP:MA1-10031_NUP107_Q10331-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant

Contains

5mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2154446

Product Specific Information

For immunofluorescence on yeast cells, try MCA-39C7 diluted 1:100 to 1:500. For immunofluorescence on mammalian cells try at 1:50 to 1:100.

Target Information

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP107 may be an important drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.