Thermo Fisher Scientific ABRA1 Monoclonal Antibody (ABRA1-01)
인간 ABRA1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로 DNA 손상 복구 연구에 적합. Western blot, Flow cytometry, Immunoprecipitation에 사용 가능. 단백질 A로 정제된 액상 형태이며 4°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Assay-dependent
Flow Cytometry (Flow)
- 1–2 µg/mL
Immunoprecipitation (IP)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ABRA1-01 |
| Immunogen | Recombinant protein corresponding to amino acids 1–313 of ABRA1 with N-terminal His6 tag |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157457 |
Product Specific Information
This antibody recognizes human ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAGE under reducing conditions.
Target Information
CCDC98 (Abraxas 1) was identified through protein binding studies using BRCA1 as the binding target. It recruits RAP80, a ubiquitin-binding protein, to BRCA1, enabling BRCA1 foci formation in response to DNA damage. Both CCDC98 and RAP80 are essential for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either protein show increased sensitivity to ionizing radiation, though less than BRCA1-deficient cells, indicating a partial role in BRCA1-mediated DNA damage response. At least two isoforms of CCDC98 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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