Thermo Fisher Scientific ABRA1 Monoclonal Antibody (ABRA1-01)

Applications

Western Blot (WB)

• Assay-dependent

Flow Cytometry (Flow)

• 1–2 µg/mL

Immunoprecipitation (IP)

• Assay-dependent

Product Specifications

Product Specific Information

This antibody recognizes human ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAGE under reducing conditions.

Target Information

CCDC98 (Abraxas 1) was identified through protein binding studies using BRCA1 as the binding target. It recruits RAP80, a ubiquitin-binding protein, to BRCA1, enabling BRCA1 foci formation in response to DNA damage. Both CCDC98 and RAP80 are essential for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either protein show increased sensitivity to ionizing radiation, though less than BRCA1-deficient cells, indicating a partial role in BRCA1-mediated DNA damage response. At least two isoforms of CCDC98 are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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