Thermo Fisher Scientific CEA (CEACAM5) Monoclonal Antibody (OTI2B12), TrueMAB

Applications and Tested Dilution

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CEA (Carcino Embryonic Antigen, CD66e) is synthesized during fetal gut development and re-expressed in intestinal carcinomas and other tumors.
It belongs to the immunoglobulin supergene family and includes one N domain and six constant-like domains (A1–A3, B1–B3).
CEA antibodies aid in identifying metastatic adenocarcinomas and differentiating pulmonary adenocarcinomas (CEA+) from pleural mesotheliomas (rarely or weakly CEA+).

CEA is a glycoprotein tumor marker found in adenocarcinomas of endodermally derived digestive epithelium and fetal colon.
The CEA family includes cell adhesion molecules and pregnancy-specific glycoproteins located on chromosome 19.
The encoded protein mediates cell adhesion and is involved in tissue differentiation, angiogenesis, apoptosis, tumor suppression, metastasis, and immune modulation.
Multiple transcript variants encoding different isoforms have been reported.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.