Thermo Fisher Scientific Phospho-DAXX (Ser739) Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Predicted to react with Mouse and Rat samples.

Target Information

This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with various proteins such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1.
In the nucleus, it functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli.
This protein also associates with centromeres in G2 phase. In the cytoplasm, it may regulate apoptosis. The subcellular localization and function are modulated by post-translational modifications, including sumoylation, phosphorylation, and polyubiquitination.
Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.