Thermo Fisher Scientific Thymidylate Synthase Monoclonal Antibody (SP112)
Thymidylate Synthase 단백질을 인식하는 Rabbit monoclonal antibody (Clone SP112). 인체 시료에 반응하며 IHC(P) 및 Flow Cytometry에 사용 가능. 열매개 항원 회복 권장. DNA 합성 관련 TS 단백질 연구에 적합.
- 카탈로그번호
- MA516405
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100
Flow Cytometry (Flow)
- Tested Dilution: 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SP112 |
| Immunogen | Synthetic peptide near C-terminus of human Thymidylate Synthase (TS) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.113 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.2, with 1% BSA |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537924 |
Product Specific Information
Heat-mediated antigen retrieval is recommended prior to staining, using an EDTA buffer for 10 minutes followed by cooling at room temperature for 20 minutes.
Following antigen retrieval, incubate samples with primary antibody for 10 minutes at room temperature.
A suggested positive control is colon carcinoma or tonsil tissue.
Target Information
Thymidylate Synthase (TS) converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis.
TS is a critical target for fluoropyrimidines, an important group of antineoplastic drugs used in the treatment of solid tumors.
Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP, which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate.
Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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