Thermo Fisher Scientific Arginase 1 (ARG1) Monoclonal Antibody (OTI3C8)

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, the final step in the urea cycle. The resulting polyamines are essential for cell proliferation and detoxification of byproducts from protein degradation.
By degrading arginine, Arginase 1 limits substrate availability for NO synthase, thus down-regulating nitric oxide production.

In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid-derived suppressor cells (MDSCs), and neural stem cells.
In humans, expression occurs in blood neutrophils but not in CCR3+ granulocytes.
In mice, Arginase 1 expression is a hallmark of alternatively activated macrophages (M2a).
It may also be expressed in myeloid cells infiltrating tumors and is typically present in most hepatocellular carcinomas.
Defects in Arginase 1 cause argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.