Thermo Fisher Scientific Symplekin Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.
• Based on 100% sequence identity, this antibody is predicted to react with Mouse.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and serves as a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes (T helper cells), but may also be expressed by monocytes, macrophages, and dendritic cells.
At the tissue level, CD4 expression can be detected in thymus, lymph nodes, tonsils, spleen, and in specific regions of the brain, gut, and other non-lymphoid tissues.
CD4 functions to initiate or augment early T-cell activation through association with the T-cell receptor complex and protein tyrosine kinase Lck. It may also act as a mediator of neuronal damage in infectious and immune-mediated diseases of the central nervous system.
Multiple alternatively spliced transcripts have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.