Thermo Fisher Scientific Phospho-INSR (Tyr1185) Polyclonal Antibody
Human INSR Tyr1185 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. 다양한 종과 반응 예측됨. Protein A 및 항원 친화 크로마토그래피로 정제. 액상 형태로 제공되며, 연구용으로만 사용.
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Applications
- Dot blot (DB)
Tested Dilution: 1:500
Publications: - References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1185 of human INSR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984008 |
Product Specific Information
This antibody is predicted to react with bovine, canine, mouse, rat, and Xenopus based on sequence homology.
Target Information
INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes, and IGF-1R defects may also cause some forms of growth retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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