Thermo Fisher Scientific SPINK5 Polyclonal Antibody
SPINK5 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 인간 및 생쥐 반응성. 아피니티 크로마토그래피로 정제되었으며, PBS 버퍼에 50% 글리세롤 포함. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SPINK5 (Accession Q9NQ38), corresponding to amino acid residues C151–F201 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851291 |
Product Specific Information
Antibody detects endogenous levels of total SPINK5.
Target Information
Lympho-epithelial Kazal-type inhibitor (LEKTI) is a serine protease inhibitor that protects mucous epithelia against microbial attack and inflammation. LEKTI is a marker of epithelial differentiation and is strongly expressed in the granular and uppermost spinous layers of the epidermis, as well as in differentiated layers of stratified epithelia.
Defects in SPINK5, the gene encoding LEKTI, cause Netherton syndrome, a severe autosomal recessive disorder characterized by atopic dermatitis, hayfever, and other conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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