Thermo Fisher Scientific PDIR Polyclonal Antibody
Thermo Fisher Scientific의 PDIR Polyclonal Antibody는 인간 PDIR 단백질을 검출하는 토끼 IgG 기반 항체입니다. Western blot과 면역세포화학(ICC/IF)에 적합하며, 비결합형 액상 형태로 제공됩니다. 연구용으로 사용되며 ER 내 단백질 접힘 과정 연구에 유용합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:250 | View publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues T(498) N Y I R A L R E G D H E R L G K K(515) of human PDIR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2252095 |
Product Specific Information
PA3-007 detects PDIR protein in human samples.
It has been successfully used in Western blot procedures.
By Western blot, this antibody detects an ~58 kDa protein representing PDIR in human fibrosarcoma HT 1080 cell lysate.
To a lesser extent, this antibody also detects two nonspecific bands at 47 and 30 kDa.
The immunogen peptide (Cat. # PEP-226) is available for neutralization and control experiments.
Target Information
PDIR (protein disulfide isomerase-related protein) is a novel PDI protein originally isolated from a human placental cDNA library.
It contains three CXXC-like motifs (Cys-Ser-Met-Cys, Cys-Gly-His-Cys, Cys-Pro-His-Cys) characteristic of the PDI superfamily, responsible for oxidoreductase activity.
PDIR also possesses a putative endoplasmic reticulum (ER) retention signal Lys-Glu-Glu-Leu at its carboxyl terminus, indicative of ER resident proteins.
Northern blot analysis shows preferential expression in cells actively secreting proteins, and expression is stress-inducible.
PDIR facilitates disulfide bond formation and protein folding within the ER lumen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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