Thermo Fisher Scientific WDR35 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human WDR35. Recombinant protein control fragment (Product #RP-99642). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:WDR35,uniProtId:Q9P2L0-1,ncbiNodeId:9606,antigenRange:530-634,antigenLength:1181,antigenImageFileName:PA5-60629_WDR35_Q9P2L0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60629_WDR35_Q9P2L0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649570

Product Specific Information

Immunogen sequence: SLPNVGLIQK YSLNCRAYQL SLNCNSSRLA IIDISGVLTF FDLDARVTDS TGQQVVGELL KLERRDVWDM KWAKDNPDLF AMMEKTRMYV FRNLDPEEPI QTSGY

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

Target Information

WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR35, also known as CED2, has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED), an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.