Thermo Fisher Scientific Phospho-SP1 (Thr453) Polyclonal Antibody
SP1 단백질의 Thr453 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF에 사용 가능하며 Human, Mouse, Rat 반응. 고순도 정제 및 PBS/glycerol 저장, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SP1 (Accession P08047), corresponding to amino acid residues around phosphorylated Thr453 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816243 |
Product Specific Information
This antibody detects endogenous levels of SP1 only when phosphorylated at Threonine 453.
Target Information
SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. It binds with high affinity to GC-rich motifs and regulates the expression of numerous genes involved in cell growth, apoptosis, differentiation, and immune responses. SP1 activity is highly regulated by post-translational modifications such as phosphorylation, sumoylation, proteolytic cleavage, glycosylation, and acetylation. It also binds the PDGFR-alpha G-box promoter and may modulate the cellular response to DNA damage. SP1 is implicated in chromatin remodeling and plays a role in recruiting SMARCA4/BRG1 to the c-FOS promoter, as well as regulating FE65 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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