Thermo Fisher Scientific Phospho-IGF1R (Tyr1165, Tyr1166) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phosphorylated IGF1R (Tyr1165, Tyr1166). Suitable for WB, IHC, and ICC applications. Supplied as unconjugated liquid form at 1 mg/mL. Stored at -20°C for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IGF1R around the phosphorylation site of Tyr1165/Tyr1166 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816245 |
Target Information
IGF1R (Insulin-like Growth Factor 1 Receptor) is a receptor tyrosine kinase activated by IGF-1 and IGF-2. It plays a key role in cell growth and survival and is implicated in various cancers. The receptor is a tetramer composed of two alpha and two beta subunits. The alpha subunits bind IGF-1 with higher affinity than IGF-2, triggering autophosphorylation at Tyr1134, Tyr1135, and Tyr1136. Activated IGF1R subsequently phosphorylates substrate proteins, leading to activation of RAS, RAF, and MAPK pathways (ERK, p38, JNK), which promote gene transcription and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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