Thermo Fisher Scientific Phospho-RET (Tyr1062) Polyclonal Antibody
RET 단백질의 Tyr1062 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot과 Immunocytochemistry에 적합. 인간, 생쥐, 랫트 반응성. 고순도 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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- PA5104769
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RET (Accession P07949), corresponding to amino acid residues around phosphorylated Tyr1062. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816242 |
Product Specific Information
This antibody detects endogenous levels of RET only when phosphorylated at Tyrosine 1062.
Target Information
The receptor tyrosine kinase RET is a member of the cadherin superfamily and plays a crucial role in neural crest development. RET can undergo oncogenic activation by cytogenetic rearrangement and transduces signals for cell growth and differentiation.
Mutations in the RET gene are associated with multiple endocrine neoplasia type IIA and IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene, with additional variants of uncertain biological validity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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