Thermo Fisher Scientific Phospho-beta-2 Adrenergic Receptor (Ser346) Polyclonal Antibody
Phospho-beta-2 Adrenergic Receptor (Ser346)에 특이적인 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 1 mg/mL 농도의 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ADRB2 (Accession P07550), corresponding to amino acid residues around phosphorylated Ser346 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816240 |
Product Specific Information
This antibody detects endogenous levels of ADRB2 only when phosphorylated at Serine 346.
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor (GPCR) superfamily that bind the endogenous catecholamines epinephrine and norepinephrine.
Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family.
Nine receptor subtypes have been identified, including:
- Three alpha-1 AR subtypes (1A/D, 1B, 1C)
- Three alpha-2 ARs (2A, 2B, 2C)
- Three beta AR subtypes (1, 2, 3)
ARs are involved in the onset or maintenance of several disease states, including:
- Hypertension
- Cardiac dysfunction (congestive heart failure, ischemia, arrhythmias)
- Diabetes
- Glaucoma
- Depression
- Impotence
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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