Thermo Fisher Scientific BFAR Polyclonal Antibody
BFAR 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, IP에 사용 가능. 인간 단백질에 반응하며, 세포 사멸 경로 연구에 적합. 액상 형태로 제공되며 4°C 또는 -20°C에서 보관.
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- PA572900
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to amino acids 1–139 of human BFAR (GenBank No. NP_057645.1). Human BFAR is a 450 amino acid protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718754 |
Target Information
The bifunctional apoptosis regulator (BFAR) is a scaffold protein that integrates signaling components of the apoptosis-regulatory machinery. It is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors (extrinsic pathway) as well as mitochondria-dependent apoptosis (intrinsic pathway). BFAR interacts with Bcl-2 or Bcl-XL via a SAM domain, contributing to its anti-apoptotic properties. It also contains a DED-like domain that suppresses receptor-mediated apoptosis and is involved in the regulation of neuronal survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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