Thermo Fisher Scientific BFAR Polyclonal Antibody
BFAR 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), IP에 사용 가능. 인간 시료 반응성. 세포 사멸 조절 연구에 적합하며, 비결합형 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 3–21 of human BAR (GenBank no. NP_057645.1). Human BAR is a 450 amino acid protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718753 |
Target Information
The bifunctional apoptosis regulator (BFAR) is a scaffold protein that integrates signaling components of the cell’s apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors (extrinsic pathway) as well as mitochondria-dependent apoptosis (intrinsic pathway). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to its anti-apoptotic properties. Additionally, BFAR contains a DED-like domain that can suppress apoptosis mediated at the receptor level. BFAR is also thought to play a role in neuronal survival regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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