Thermo Fisher Scientific Mouse TIRAP Synthetic Peptide
Mouse TIRAP 단백질의 C-말단 15개 아미노산 서열을 기반으로 한 합성 펩타이드. 항체 PA5-20028의 블로킹 펩타이드로 사용 가능. TLR 신호전달 연구에 적합하며, 고순도 PBS 용액 형태로 제공. 연구용 전용 제품.
- 카탈로그번호
- PEP0147
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of mouse TIRAP.
PEP-0147 can be used as a blocking peptide with polyclonal antibody PA5-20028.
Target Information
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors.
In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling.
Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-βB and MAP kinase activation, suggesting that TIRAP is also involved in TLR4 signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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