Thermo Fisher Scientific Human CARD8 Synthetic Peptide
Human CARD8 단백질의 C-말단 15 아미노산 서열에 해당하는 합성 펩타이드. PA5-20031 항체의 블로킹 펩타이드로 사용 가능. 세포사멸 관련 연구용으로 적합하며, 액상 형태로 제공. PBS(pH 7.2) + 0.1% BSA 용액에 보관, -20°C에서 저장.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human CARD8.
PEP-0150 can be used as a blocking peptide with polyclonal antibody PA5-20031.
Target Information
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD-containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC.
A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis, and caspase-1 and its related proteins ICEBERG and pseudo-ICE. Although there are conflicting reports on whether CARD8 acts as a pro- or anti-apoptotic protein, it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappa-B activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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