Thermo Fisher Scientific Mouse Caspase 12 Synthetic Peptide
마우스 Caspase-12의 대형 절단 산물 내 18개 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-20033의 블로킹 펩타이드로 사용 가능. ER 스트레스 유도 세포사멸 연구에 활용. 정제된 액상 형태로 -20°C 보관.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids within the large cleavage product of murine caspase-12.
PEP-0152 can be used as a blocking peptide with polyclonal antibody PA5-20033.
Target Information
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main ones, involving key apoptotic proteases caspase-8 and caspase-9, respectively. The endoplasmic reticulum (ER) stress is the third apoptotic pathway, in which caspase-12 is involved.
Caspase-12 is localized to the ER but not to cytoplasm or mitochondria. It is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 co-localizes with several ER-associated proteins implicated in Alzheimer’s disease, including γ-secretase presenilin and β-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta and is ubiquitously expressed in mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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