Thermo Fisher Scientific EGFR Polyclonal Antibody
EGFR 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합합니다. 인간 시료 반응성이 높으며, 항원 친화 크로마토그래피로 정제되어 고순도 제품입니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from amino acids 1060–1100 near the C-terminus of human EGFR (UniProt ID: P00533-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: SKBR-3
- Cellular location: Membrane
Target Information
EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that mediates signaling in response to growth factors. Overexpression is associated with various cancers and serves as a target for biological and small molecule therapeutics.
EGFR is encoded by the EGFR gene on chromosome 7 and belongs to the HER/ERbB family, which includes ERbB2, ERbB3, and ERbB4.
Ligand binding (e.g., EGF, TGF-α) to the extracellular domain induces receptor dimerization and autophosphorylation of cytoplasmic tyrosine residues.
Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and squamous cell carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(본 제품 관련 항원 구조 이미지 및 EGFR 관련 시각 자료는 Thermo Fisher Scientific 공식 리소스를 참조하십시오.)
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