Thermo Fisher Scientific E-cadherin Monoclonal Antibody (M168)
E-cadherin 단백질을 인식하는 Mouse monoclonal antibody (Clone M168). WB, IHC, ICC/IF, IP 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Protein A 정제, PBS/BSA/glycerol buffer에 보관. 암 연구 및 세포 접착 관련 연구용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:250 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M168 |
| Immunogen | Mouse recombinant E-Cadherin protein containing amino acids in the cytoplasmic region. Highly conserved in human and rat E-cadherin. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942631 |
Product Specific Information
This E-cadherin antibody detects a 120 kDa protein in human A431 cells, and does not cross-react with VE-cadherin or N-cadherin.
Target Information
E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily. It is a cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. Mutations in this gene are associated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of E-cadherin function contributes to cancer progression by increasing proliferation, invasion, and metastasis. The ectodomain mediates bacterial adhesion, while the cytoplasmic domain is required for internalization. E-cadherin plays a key role in tissue architecture and integrity. In humans, it is encoded by the CDH1 gene on chromosome 16. Reduced or lost expression of E-cadherin in carcinomas correlates with higher invasion and metastasis potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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