Thermo Fisher Scientific HLA-G (soluble) Monoclonal Antibody (5A6G7), PE

Applications

• Flow Cytometry (Flow): 1–4 µg/mL

Product Specifications

Additional Formats

• Unconjugated (MA1-10357)
• Biotin (MA1-10360)
• Request custom conjugation (Custom Form)

Product Specific Information

This antibody was generated to a peptide corresponding to the C-intron 4-encoded sequence. It does not cross-react with the full-length HLA-G1 isoform, allowing clear distinction between secreted HLA-G5 and HLA-G6 isoforms and shedded HLA-G1.

Target Information

HLA-G belongs to the HLA class I heavy chain paralogues. This molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain (~45 kDa) is membrane-anchored and encoded by a gene with 8 exons:

• Exon 1: Leader peptide
• Exons 2–3: α1 and α2 domains (peptide-binding)
• Exon 4: α3 domain
• Exon 5: Transmembrane region
• Exon 6: Cytoplasmic tail

HLA-G is expressed on fetal-derived placental cells.
HLA and MHC antibodies are essential tools in Immunopeptidomics, supporting the identification and characterization of neoantigens via LC-MS/MS.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.

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