Thermo Fisher Scientific HLA-G (soluble) Monoclonal Antibody (2A12), FITC

Thermo Fisher Scientific HLA-G (soluble) Monoclonal Antibody (2A12), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 1–5 µg/mL
Publications: (참조 없음)

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Product Specific Information

This antibody was generated to a peptide corresponding to C-intron 4-encoded sequence.
It does not cross-react with the full-length HLA-G1 isoform and thus allows distinction between secreted HLA-G5 and HLA-G6 isoforms from shedded HLA-G1.

Target Information

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane and is approximately 45 kDa.
The gene contains 8 exons:

• Exon 1: leader peptide
• Exons 2–3: alpha1 and alpha2 domains (peptide-binding)
• Exon 4: alpha3 domain
• Exon 5: transmembrane region
• Exon 6: cytoplasmic tail

HLA-G is expressed on fetal-derived placental cells.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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