Thermo Fisher Scientific HLA-G Monoclonal Antibody (87G), FITC

Thermo Fisher Scientific HLA-G Monoclonal Antibody (87G), FITC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 2 µg/mL
Publications: View 1 publication

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 488
• Biotin
• PE
• Custom conjugation available

Product Specific Information

This antibody recognizes both membrane-bound and soluble forms of HLA-G (HLA-G1 and HLA-G5).
HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and is expressed on the surface of trophoblast cells.
It does not cross-react with mouse or rat.

Target Information

HLA-G is one of the HLA class I heavy chain paralogues.
It forms a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin).
The heavy chain (~45 kDa) gene contains 8 exons:

1. Exon 1: leader peptide
2. Exons 2–3: α1 and α2 domains (peptide binding)
3. Exon 4: α3 domain
4. Exon 5: transmembrane region
5. Exon 6: cytoplasmic tail

HLA-G is expressed on fetal-derived placental cells.
HLA and MHC antibodies are crucial in Immunopeptidomics, enabling identification and characterization of neoantigens via LC-MS/MS analysis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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