Thermo Fisher Scientific CD86 Monoclonal Antibody (BU63), PE-Cyanine5
인간 CD86 단백질을 인식하는 마우스 단클론 항체로, PE-Cyanine5로 표지되어 있습니다. Flow Cytometry에 적합하며, 항원제시세포의 CD86 발현 분석에 사용됩니다. 4°C에서 암소 보관, 동결 금지.
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Applications
- Flow Cytometry (Flow): 4 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BU63 |
| Immunogen | B-lymphoblastoid cell line ARH 77 |
| Conjugate | PE-Cyanine5 |
| Excitation / Emission Max | 568 / 666 nm |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898666 |
Additional Formats
- Unconjugated (MA1-10293)
- APC (MA1-10294)
- FITC (MA1-10295)
- PE (MA1-10296)
- PE-Cyanine7 (MA5-38755)
- PerCP (MA1-10297)
- Custom conjugation available
Product Specific Information
This antibody reacts with an extracellular epitope of CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of the immunoglobulin superfamily. It is expressed on professional antigen-presenting cells such as dendritic cells, macrophages, and activated B lymphocytes.
Target Information
CD86 is one of two ligands (the other being CD80) for CTLA4 and CD28. It acts as a costimulatory molecule essential for T-cell activation during antigen presentation. Insufficient co-stimulation involving CD86/CD80 can lead to immune tolerance. CD86 is a type I membrane protein expressed by antigen-presenting cells and serves as a ligand for CD28 and CTLA4 on T cells. Binding to CD28 provides a stimulatory signal for T-cell activation, while binding to CTLA4 inhibits activation and reduces immune responses. Alternative splicing produces multiple isoforms of CD86. Dysregulation of CD86 has been associated with diseases such as gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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