Thermo Fisher Scientific ALX4 Monoclonal Antibody (OTI2F2), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The ALX4 gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue.
Mutations in this gene are associated with:

• Parietal foramina 2 (PFM2), an autosomal dominant disorder causing deficient ossification of the parietal bones
• Frontonasal dysplasia with alopecia and hypogonadism, implicating roles in craniofacial development and hair follicle formation
• Potocki-Shaffer syndrome (PSS), linked to deletions in chromosome 11 (p11p12) causing craniofacial anomalies and multiple exostoses

In mouse models, ALX4 utilizes dual translation initiation sites located 16 codons apart.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.