Thermo Fisher Scientific ALX4 Monoclonal Antibody (OTI1F2), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The ALX4 gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue.
Mutations in this gene are associated with:

• Parietal foramina 2 (PFM2), an autosomal dominant disorder affecting parietal bone ossification
• A form of frontonasal dysplasia with alopecia and hypogonadism, indicating a role in craniofacial and hair follicle development
• Deletion of chromosome 11 segment containing this gene (del(11)(p11p12)) causes Potocki-Shaffer syndrome (PSS), characterized by craniofacial anomalies, intellectual disability, multiple exostoses, and genital abnormalities in males

In mice, this gene utilizes dual translation initiation sites located 16 codons apart.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.