Thermo Fisher Scientific ASK Recombinant Rabbit Monoclonal Antibody (0S8I5)
Thermo Fisher Scientific의 ASK Recombinant Rabbit Monoclonal Antibody (Clone 0S8I5)는 인간 DBF4 단백질을 표적으로 하는 고특이성 항체입니다. Western blot과 ELISA에 최적화되어 있으며, HEK293 발현 시스템에서 생산된 recombinant IgG 형식입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 0S8I5 |
| Immunogen | A synthetic peptide corresponding to amino acids 1–100 of human DBF4 (Q9UBU7) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.35 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911877 |
Product Specific Information
Positive test controls include PC-3 and Jurkat cell lines.
Immunogen sequence:
MNSGAMRIHS KGHFQGGIQV KNEKNRPSLK SLKTDNRPEK SKCKPLWGKV FYLDLPSVTI SEKLQKDIKD LGGRVEEFLS KDISYLISNK KEAKFAQTLG
Target Information
Activator of S phase kinase (ASK, DBF4) is a regulatory subunit of the human Cdc7 kinase complex that plays a pivotal role in the G1/S cell cycle transition. Elevated ASK expression in late G1 contributes to increased Cdc7 kinase activity at the G1/S boundary. ASK interacts with replication origins, suggesting that Cdc7 may trigger S phase by activating replication initiation complexes. ASK and Cdc7 are involved in regulating DNA replication initiation by targeting MCM2 protein. The nuclear localization and chromatin binding of ASK increase at late G1 phase, potentially requiring additional signals. ASK may also functionally interact with menin, a tumor suppressor mutated in MEN1, in cell proliferation regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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