Thermo Fisher Scientific TRPC4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in mouse, human, and many other species.
• Specificity of this antibody: TRPC4 (see also the immunogen).

Target Information

TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels.
It forms a non-selective calcium-permeable cation channel activated by Gq-coupled receptors and tyrosine kinases.
TRPC4 is involved in processes such as endothelial permeability, vasodilation, neurotransmitter release, and cell proliferation.
Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for TRPC4.

The classical or canonical transient receptor potential (TRPC) channels (TRPC1–7) are the subfamily most closely related to the Drosophila TRP channel.
Diseases associated with TRPC4 include photosensitive epilepsy.

CaV3.3 encodes the pore-forming alpha subunit of a voltage-gated calcium channel and is a member of the low voltage-activated, T-type calcium channels.
CaV3.3 channels exhibit slower activation and inactivation compared to other T-type calcium channels and may be involved in neuronal calcium signaling.
Voltage-gated calcium channels (CaV) mediate calcium influx in response to depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression.
Diseases associated with CACNA1I include Childhood Absence Epilepsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.