Thermo Fisher Scientific TRPV6 Polyclonal Antibody
TRPV6 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체. Western blot 및 IHC에 적합하며, 양(Sheep) 유래 IgG 형태로 제공. 합성 펩타이드를 면역원으로 사용하며, 연구용으로 칼슘 채널 관련 단백질 분석에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the 4th cytoplasmic loop of rat TRPV6 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2209544 |
Product Specific Information
Reconstitute with 100 µL of distilled water.
Target Information
Calcium-permeable channels, such as TRPV6, participate in neurotransmission, muscle contraction, and exocytosis by providing calcium as an intracellular second messenger. Depending on the tissue, transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
TRPV6 is a calcium-selective cation channel involved in Ca²⁺ uptake in various tissues, including intestinal Ca²⁺ reabsorption. The channel is activated by low internal calcium levels and exhibits inward rectification.
Inactivation includes both rapid Ca²⁺-dependent and slower Ca²⁺-calmodulin-dependent mechanisms, possibly regulated by phosphorylation. In vitro, it is slowly inhibited by Mg²⁺ in a voltage-independent manner.
TRPV6 forms heteromeric assemblies with TRPV5, modifying channel properties. TRPV5-TRPV6 heteromultimers exhibit voltage-dependent gating. It interacts with TRPV5, S100A10, ANAX2-S100A10 heterotetramer, BSPRY, and calmodulin. The interaction with S100A10 is required for trafficking to the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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