Thermo Fisher Scientific TRPM4 Polyclonal Antibody
TRPM4 단백질을 인식하는 Thermo Fisher Scientific의 sheep polyclonal antibody. Western blot, IHC, ICC/IF에 사용 가능. 합성 펩타이드 항원 기반, 비결합형 형태로 제공. 연구용으로 세포 신호 및 칼슘 조절 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Mouse |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse TRPM4 conjugated to blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1091055 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- OST00027W can be used with blocking peptide GST00013P.
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Target Information
Calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization. Activated by increased intracellular Ca²⁺ but impermeable to it. Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization. Plays a central role in cardiomyocytes, neurons (entorhinal cortex, dorsal root, vomeronasal), endocrine pancreas cells, kidney epithelial cells, cochlea hair cells, etc.
Participates in T-cell activation by modulating Ca²⁺ oscillations after T lymphocyte activation, required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries and controls insulin secretion in pancreatic beta-cells. May contribute to pacemaking or irregular electrical activity under Ca²⁺ overload. Affects Th1 and Th2 cell motility and cytokine production through calcium signaling and NFATC1 localization. Enhances cell proliferation via up-regulation of the beta-catenin signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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