Thermo Fisher Scientific TRPM4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Glycerol (1:1) may be added for additional stability.
• OST00027W can be used with blocking peptide GST00013P.
• Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Target Information

Calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization. Activated by increased intracellular Ca²⁺ but impermeable to it. Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization. Plays a central role in cardiomyocytes, neurons (entorhinal cortex, dorsal root, vomeronasal), endocrine pancreas cells, kidney epithelial cells, cochlea hair cells, etc.

Participates in T-cell activation by modulating Ca²⁺ oscillations after T lymphocyte activation, required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries and controls insulin secretion in pancreatic beta-cells. May contribute to pacemaking or irregular electrical activity under Ca²⁺ overload. Affects Th1 and Th2 cell motility and cytokine production through calcium signaling and NFATC1 localization. Enhances cell proliferation via up-regulation of the beta-catenin signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.