Thermo Fisher Scientific PON3 Monoclonal Antibody (OTI1A5), TrueMAB
인간 PON3 단백질(aa 30-319)을 항원으로 제작된 마우스 단클론 항체입니다. Western blot 및 파라핀 IHC에 사용 가능하며, carrier-free 형태로 재결합 및 결합 실험에 적합합니다. 고순도 친화 크로마토그래피 정제, -20°C 보관.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 30–319 of human PON3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase associated with apoA-I in HDL, preventing LDL oxidation and atherogenic oxidised-LDL formation.
Polymorphisms of the human PON1 gene are linked to coronary artery disease. PON1 activity is lower in subjects prone to atherosclerosis (e.g., diabetes, familial hypercholesterolemia, renal disease).
PON2 protects cells against oxidative damage, while PON3 shows similar activity to PON1 but with different substrate specificity.
PON1 and PON3 are implicated in lowering coronary artery disease and atherosclerosis risk.
Human PON3 shares three conserved cysteine residues with PON1, emphasizing their importance in vivo.
PON1-based catalytic scavengers may provide safe and effective protection against organophosphate intoxication.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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